The E would obviously benefit from hybrid assist especially for stop and go city driving. FWD helps somewhat, although starting and stopping 5K lbs. around town is bound to take its toll. For mine as others around here, highway travel mileage yield is very reasonable and if you're fortunate enough to get a draft break from a semi or other large truck in front, the performance is anywhere from good to great. My lows and highs are 20 to about 27; somewhere around low to mid-20s for the global average mix of city and highway, which I find decent and acceptable given the safety and comfort aspects. No doubt about it, newer/newest vehicles tend to yield exceptional mileage, including surprisingly enough, RWD models as well.
2010 Silver Green CXL2, FWD, Titanium with Dark Titanium Accents, Leather Seats